Thread Tools
Old 05-11-2004, 12:52 AM
Guest
Join Date: Aug 2000
Posts: 3,996
Massive Acid (LSD) Overdose Effects

Disclaimer: this post in no way advocates or describes the use of illegal drugs.

The claim is often made that one cannot "overdose" on LSD - that no plausible amount of this drug taken will result in death. However, LSD is a very potent drug, and several grams of the stuff would be equivalent to tens of thousands of a typical street dose. What would happen if someone ingested such an amount? I find it hard to believe that the results would be harmless. Are there any recorded instances of mega-overdoses of LSD and their repercussions? It seems like any drug that could have this powerful a psychotropic effect on the mind would result in permanent incapacitation or death as a result of a megadose. Any studies or other documented or observed instances of the results of such doses are appreciated.
Old 05-11-2004, 01:11 AM
Guest
Join Date: Apr 2004
Posts: 245
I think maybe the point was that LSD isnt dangerous, its what you do thats dangerous.


You lose your mind, litreally.
Old 05-11-2004, 01:51 AM
Guest
Join Date: Jul 1999
Location: The Brink
Posts: 11,314
This page gives a little info on hypothetical fatal LSD overdoses, and suggests that for an 80kg (176 lb) human, a lethal dose might be between 16 and 80 mg. of extremely pure LSD. (That'd be about 50 to 250 "hits," apparently.)

Alternately, I suppose it'd be possible for a human to be killed by LSD without actually being poisoned by it...like, say, if you were hit on the head by a 55 Gallon Drug filled with LSD. Or if a crate of LSD fell on you in an abandoned warehouse, pinning you underneath it until you starved.
Old 05-11-2004, 01:54 AM
Guest
Join Date: Jan 2003
Location: Denver, CO
Posts: 827
Well, I am not a doctor, chemist, or drug user, so take this as you will.

I would expect drugs that can cause overdoses to have a physical as well as a mental reaction: cocaine increases heart rate and morphine decreases it, for example. If LSD stimulates only "mental" functions of the brain (optic centers, "consciousness", etc) without affecting any of the limbic systems (heart, lungs, etc), than more of the drug won't cause an overload or shutdown of the body.

I think the point may have been that if you took a subject, restrained them (so they couldn't take any actions to hurt themselves) and gave them a megadose of LSD, their body would have no ill effects. Of course, I wouldn't be surprised if a dose of sufficient size could "burn out" the subject's brain, leaving them a vegetable, but their body could just keep on ticking.

Great, it's on that pleasent note that I'm off to bed...

Urk, although on preview the link in Ranchoth's post is even more disturbing...
__________________
Never attribute to malice that which can be explained by stupidity.
Old 05-11-2004, 02:10 AM
Member
Join Date: May 2001
Location: Sydney, Australia
Posts: 17,749
I remember reading an article some years ago about a famous Australian murder mystery, Bogle and Chandler. They and their friends were scientists and quite the trendy party animals. Both were married to other people and were found deal in a public park with no apparent cause. A pathologist in the article speculated that LSD could have been the poison used because its metabolites cannot be found after exposure to light and the process of an ordinary autopsy in 1963.

Actually I just found this which indicates that LSD was established as the cause of death.
Old 05-11-2004, 02:10 AM
Charter Member
Join Date: Jan 2003
Location: Richmond, VA
Posts: 22,536
From an MSDS for LSD:
Quote:
TOXICITY:

LYSERGIC ACID DIETHYLAMIDE:
700 NG/KG ORAL-HUMAN TDLO; 2857 NG/KG ORAL-HUMAN TDLO; 857 NG/KG ORAL-HUMAN
TDLO; 750 NG/KG INTRAMUSCULAR-HUMAN TDLO; 16 MG/KG INTRAVENOUS-RAT LD50;
50 MG/KG INTRAPERITONEAL-MOUSE LD50; 46 MG/KG INTRAVENOUS-MOUSE LD50; 300
UG/KG INTRAVENOUS-RABBIT LD50; 16 MG/KG SUBCUTANEOUS-GUINEA PIG LD50;
1800 UG/KG ORAL-WILD BIRD LD50...
__________________
SnUgGLypuPpY -- TakE BaCk tHe PiT!
Old 05-11-2004, 06:44 AM
Guest
Join Date: Dec 2002
Location: Synaesthetic Glide
Posts: 3,019
Quote:
Originally Posted by Q.E.D.
From an MSDS for LSD:
The TDL0 in your cite, refers to 'lowest dose that causes a toxic effect'. The figure 700 ng/kg translates to 49 micrograms for an individual weighing 70 kg. That is a 'threshold dose' and is also a 'toxic dose' only if you consider the tripping itself to be a toxic effect. The LD50s are more relevant to the OP's question, but don't indicate anything by themselves. In humans, the LD50 has been estimated to be around 15 mg, via interspecies scaling. This is not an empirical determination. Indeed, only one death has been reported to be due to the pharmacological effects of LSD (see 3rd entry under 'LD50 Sources').

The caveat here is that 'behavioural toxicity' is a lot more of a concern than 'physical toxicity'. In plainspeak, behavioural toxicity can refer to tripping itself or "losing your mind" or "losing your mind and having lethal/fatal injury inflicted", depending on who the speaker/writer is. In this regard, LSD's effects are indeed unpredictable. You can have a bad trip on 60 micrograms and a pleasant one on 300 micrograms. However, above ~400 micrograms, the chances of having a bad trip increase substantially.
Old 05-11-2004, 08:08 AM
Guest
Join Date: Dec 2003
Location: Milwaukee
Posts: 7,385
Re: cite from Ranchoth.

I know you just cited it, so not going at you. But who the fuck would have stats on the effect of LSD on an elephant???
__________________
Christians have the best sects.
Old 05-11-2004, 08:13 AM
Guest
Join Date: Dec 2002
Location: Over by dere
Posts: 27,023
I had a friend who had a bag of LSD laying out and her cat got into it. They called LSD Rescue (which you could actually DO in the late 60s, early 70s). The cat lived.
__________________
The poster formerly known as "EchoKitty"
Old 05-11-2004, 05:42 PM
Guest
Join Date: Aug 2000
Posts: 3,996
Thanks all, and Gyan, for finding the estimated LD-50.
Old 05-11-2004, 10:46 PM
Guest
Join Date: Jul 2003
Location: East Lansing, MI
Posts: 2,687
http:http://dextromethorphan.ws/lsd-a...dose-death.pdf

This is a peer reviewed medical journal article I have on my site about a fatal LSD overdose.
Old 05-12-2004, 02:02 AM
Guest
Join Date: Dec 2001
Location: Sydney
Posts: 2,265
Quote:
Originally Posted by don't ask
I remember reading an article some years ago about a famous Australian murder mystery, Bogle and Chandler. They and their friends were scientists and quite the trendy party animals. Both were married to other people and were found deal in a public park with no apparent cause. A pathologist in the article speculated that LSD could have been the poison used because its metabolites cannot be found after exposure to light and the process of an ordinary autopsy in 1963.

Actually I just found this which indicates that LSD was established as the cause of death.
And another theory was that the poison was dog wormer. Another theory is trifluoroacetic acid. The LSD one is not taken very seriously from my readings.
Old 05-12-2004, 02:29 AM
Guest
Join Date: Dec 2001
Location: Sydney
Posts: 2,265
From Clinical Toxicology. 8(2):191-203, 1975.

Quote:
Eight patients were seen within 15 min of intranasal self-administration of large amounts of pure D-lysergic acid diethylamide (LSD) tartrate powder. Emesis and collapse occurred along with sign of sympathetic overactivity, hyperthermia, coma, and respiratory arrest. Mild generalized bleeding occurred in several patients and evidence of platelet dysfunction was present in all. Serum and gastric concentrations of LSD tartrate ranged from 2.1 to 26 ng/ml and 1000 to 7000 mug/100 ml, respectively. With supportive care, all patients recovered. Massive LSD overdose in humans is life-threatening and produces striking and distinctive manifestations.
Old 05-12-2004, 09:28 AM
Guest
Join Date: Dec 2002
Location: Synaesthetic Glide
Posts: 3,019
antechinus: I did a cursory search, but didn't find any indications as to the equivalent volume of blood serum (blood w/u clotted solids) in a human body. In other words, 2.1 ng/ml in serum corresponds to how much LSD in 4.7 litres of blood?
Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off

Forum Jump


All times are GMT -5. The time now is 07:24 PM.

Copyright © 2017
Best Topics: kava kava reddit pokeweed berries poisonous anapestic beat isp cache horse mph gas fireplace scents playatmcd.com winners karen or pam hello operator songs parachute blankets why chopsticks translate la bomba mildest cigarette pressured into sex anger song lyrics synonym for fired anhedral wings mg 250dfx thinning silicone caulk maggots fly mexican table cream boiling beef define bogarting 1800got junk prices gay communal showers diaper torture ammonium and bleach small midgets mcdonalds grimace lv 426 bible double action 1911 friday stealing boxes periscope depth growth exponential tv buzzing noise shower knob won't turn off does a magnet stick to aluminum soames forsyte character analysis words that start with ñ in spanish why are blunts called l how to get wrinkles out of paper how to open car hood willy wonka we are the music makers and we are the dreamers of dreams david copperfield sawed in half microwave with nothing in it daniel boone tv theme song where can i find my blood type on my birth certificate replacing ford car keys why does mexican food make you poop my triglycerides are over 600 why is smith so common how late do fedex deliver how to use usb on direct tv box difference between cake and brownies oracle america, inc. do gold records actually play i sing the body electric meaning where to get sudafed bank of america set up automatic credit card payments how many ounces in an ice cream scoop howard hughes brewster senate hearings reeling in the years meaning ice cream truck driver salary can you make pasta roni without milk we missed you last night will a broken foot heal on its own tinted film for eyeglasses klondike big inch land co inc